Glp 1 Medications Explained
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What they are
GLP-1 receptor agonists — Ozempic, Wegovy, Mounjaro, Zepbound, Trulicity — reshape diabetes care and weight loss in 2026. Here’s a non-medical, fact-first overview of what they are, how they work, and what the cultural conversation often gets wrong. Not medical advice; talk to your doctor.
The current lineup
Glucagon-like peptide-1 (GLP-1) is a natural gut hormone released after eating. GLP-1 agonists are synthetic versions taken weekly (or daily, in older formulations) that mimic this hormone. They were originally developed for type-2 diabetes; the weight-loss effect was a discovered side effect that became the headline.
How weight loss works
Slowed gastric emptying + reduced appetite signaling. People feel full sooner and stay full longer. Average weight loss in trials: ~15% of body weight on semaglutide, ~22% on tirzepatide. Compare to behavioral-only programs at 5-7%.